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Copy Number Variant Detection (CNVs) can give wrong results when targets overlap and coverage tables are used as controls

Issue description

The Copy Number Variant Detection (CNVs) tool can generate incorrect fold change estimates when:

QIAGEN reference target tracks do not contain overlapping regions, thus analyses using these are not affected by this problem.


We recommended re-running all potentially affected analyses, providing a read mapping as the control mapping instead of a coverage table generated by QC for Targeted Sequencing.

Affected software