In this training, attendees will learn how to harness curated ‘omics datasets in OmicSoft DiseaseLand and curated research findings in IPA to discover new potential biomarkers. Using a neurological disorder as a case study, we will:
• Search public RNA-Seq datasets for tissue- and disease-specific differential expression in brain
• Identify genes whose expression correlates with our factor within a sample group
• Prioritize candidate biomarkers by disease vs. normal expression
• Simulate biomarker activity changes to determine potential mechanisms of action
Investigation of inflammatory, infectious, oncological, and other disorders can also be done using similar approach and will be highlighted during this training.
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