Glaucoma is a leading cause of blindness worldwide and thus an important disease to understand. The disease is characterized by retinal ganglion cell (RGC) death caused by axonal injury and in glaucoma patients the number of RGCs decreases due to axonal degeneration, resulting in visual dysfunction.
RNA-Seq was used to investigate the entire retinal transcriptome profile in the early stages of post-axonal injury. Sequencing data was imported to CLC Genomics Workbench for RNA-Seq, gene expression and statistical analysis.