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Biomarker and Target Discovery

Unravel the biology behind disease and treatment response. Explore and interpret your data with intuitive, visual tools. Gain insights that lead to new biomarker and target discoveries.

Quickly find answers to your biological questions.

Rapidly identify the best biomarker and target candidates based on biological characteristics most relevant to your discovery study. Our powerful and high-quality tools are driven by over 20 million scientific findings and over 500,000 samples, to save you valuable time and resources while empowering your biomarker research by driving new discoveries.

Biomarker and target discovery techniques and approaches:

  • Identify and prioritize molecular candidates 
  • RNA-seq
  • Gene expression
  • Interaction network analysis
  • Uncover potential mechanism of action
  • Explore molecules and pathways associated with disease
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Derive insights from your data to make impactful discoveries

Your journey to biomarker and target discovery involves
exploring molecules and molecular interactions at critical points in a disease-causing pathway. Our solutions enable a systems biology approach to drive your discoveries by combining genetics, genomics and cell and chemical
biology. QIAGEN IPA’s powerful causal analytics and unique visualization tools empower you to interpret many types of data with biological context and get visually intuitive and useful insights about your experimental systems. QIAGEN OmicSoft Studio and Lands bring over half a million curated public datasets to allow you to compare and structure your ‘omics data to query, visualize and accurately define potential targets and elucidate probable mechanism of action to accelerate drug development.

Tools and applications for biomarker discovery

Identify and prioritize molecular candidates

QIAGEN IPA enables the prioritization of biomarker candidates based on key biological properties to help you identify mechanisms that link markers to a disease or phenotype. QIAGEN IPA’s Analysis Match lets you evaluate how biomarker candidates behave across diverse biological contexts.

With QIAGEN OmicSoft Lands, explore thousands of curated studies, and hone-in on candidate genes to reveal patterns of expression across tissues and disease. Compare survival curves to identify candidate biomarkers representative of disease or population segments for further validation.

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RNA-seq

QIAGEN IPA offers powerful tools for deep analysis and intuitive visualization of RNA-seq and miRNA data. The Isoform View displays expression data associated with each isoform in a graphical overview. Significantly regulated isoforms in experimental data are displayed to facilitate exploration of their impact on functional protein domains with links to isoform-specific publications. IsoProfiler filters datasets to specific transcripts with unique properties that can serve as biomarkers.
Discover the full RNA-seq pipeline in our QIAGEN OmicSoft Array Suite, complete with sample metadata management and curation, to help you analyze, manage and visualize your ‘omics data.

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Gene expression

With QIAGEN OmicSoft, compare gene expression patterns and visually find genes that are down- or up-regulated to identify potential biomarkers. Use QIAGEN OmicSoft web-based Land Explorer to access hundreds of thousands of curated datasets to examine a target’s expression or mutation status across hundreds of disease categories.

QIAGEN IPA helps you understand the cause and effect of gene expression changes and identify potential targets for further exploration. Predict which upstream regulators are responsible and whether they are activated or inhibited.  Visualize downstream effects to identify which genes are likely to cause an increase or decrease in downstream biological processes.

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Interaction network analysis

With QIAGEN IPA you can better understand toxicity responses by exploring connections between drugs or targets and related genes or chemicals. Edit and expand networks based on the molecular relationships most relevant to the project.

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Uncover potential mechanism of action

Once you have candidate targets, QIAGEN IPA can help you understand the mechanism(s) of action that may bring about a desired biological or therapeutic effect by analyzing it in disease pathways or processes and help you understand how up-or-down-regulation would affect the pathway or signaling cascade​.

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Explore molecules and disease pathways

QIAGEN IPA helps you uncover details associated with a disease or biological function, such as associated molecules, drug targets, drugs known to target those molecules and more. Generate molecular profiles of diseases, phenotypes and biological processes, listing all the genes and compounds associated with the profiled term. Find, filter and prioritize genes and compounds based on your specific research question. ​

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Interested in our
biomarker and target discovery solutions?

Request a consultation with one of our bioinformatics specialists to discuss your specific research requirements.

Analysis and Visualization

Analyze NGS and 'omics data from Sample to Insight using our highly visual and specialized tools for data normalization, quality control, read mapping, gene expression and more

Content and Exploration Databases

Generate insights from complex 'omics data and deepen your understanding of the biological mechanisms hidden in your experiments

Enterprise NGS Solutions

Scale your NGS: From single-user to enterprise-friendly data analysis, our NGS enterprise solutions are scalable and support multiple users in an intuitive way