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Overview of QCI Interpret curation process

For Oncology Applications

For over two decades, QCI Interpret, QIAGEN’s clinical variant interpretation and reporting software, has combined the unmatched accuracy and consistency of QIAGEN’s proprietary expert (MD/PhD) curation with the superior efficiency of machine curation (AI-powered curation) to enable high-confidence variant interpretation and reporting.

The below graphic illustrates the curation process of QCI Interpret for Oncology.

QCI Interpret pulls content from all public and proprietary databases, clinical articles for the most relevant cancer genes, and thousands of clinical articles for somatic genes. Curation then occurs by artificial intelligence (AI) approaches, manual curation, or a combination of both. All content then goes through rigorous quality control to ensure consistency, accuracy, and reproducibility.

Unique to QCI Interpret for Oncology is the addition of content from over 500,000 somatic mutations submitted to QIAGEN's professional variant interpretation service, QCI Precision Insights (formerly N-of-One). This is de-identified patient data that provides even greater insight into real-world clinical cases.