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2020R4 Land Release Notes

In this content release, OncoLand and DiseaseLand added hundreds of new projects. If you don't see a Land of interest listed under "Select Land", please ask your OmicSoft Server administrator to check the Cloud Land Publishing function for available data.

In Case You Missed It

The latest versions of OmicSoft GTEx, Blueprint and CCLE Lands were released and mapped to Human.B38 and OmicsoftGenCode.V33. Be sure to use these Lands to get the most up-to-date data!

  • GTEx_B38_GC33: 17,000 RNA-seq samples from 51 normal tissues, as well as expression microarray data.
  • CCLE_B38_GC33: Over 1000 cancer cell lines, profiled for RNA-seq, DNA-seq mutation, CNV, DepMap Gene Dependency (CRISPR and RNAi), MS, and RPPA proteomic data.
  • Blueprint_B38_GC33: 628 normal hematopoietic cell expression profiles.

In addition, TRACERx_B38_GC33 (multi-omics non-small cell lung cancer) and DLBCL_NCI_B38_GC33 (diffuse large cell B cell lymphoma, controlled-access application required) are available on the latest gene model.

Oncoland Highlights

  • Hundreds of new projects added to OncoGEO and OncoMouse
  • Coming Soon: TCGA_B38, reprocessed on OmicSoftGenCode.V33

OncoGEO

In this release, there are 4110 new samples and 1245 new comparisons from 102 projects added to OncoGEO, focusing on renal clear cell carcinoma, hepatocellular carcinoma, glioblastoma, colon and colorectal cancers, cervix carcinoma and breast carcinoma.

Figure 1. Distribution of new oncology-focused samples in OncoGEO 2020R4, grouped on the Y-axis by Tissue and colored by DiseaseState.

Hematology

We added 1822 samples and 557 comparisons from 55 projects in this release, with new studies on multiple myeloma, acute myeloid leukemia, diffuse large B-cell lymphoma, chronic lymphocytic leukemia and more.

Figure 2. Distribution of new hematologic cancer-focused samples in Hematology 2020R4, grouped on the Y-axis by DiseaseState and colored by CellType.

OncoMouse

In this release, we added 361 samples and 121 comparisons from 19 projects to OncoMouse_B38, with new studies relevant to chronic lymphocytic leukemia, myelodysplastic syndrome, multiple myeloma, mantle cell lymphoma and more.

Figure 3. Distribution of new oncology model samples in OncoMouse 2020R4, grouped on the Y-axis by DiseaseState and colored by Tissue.

 

DiseaseLand Highlights

  • New studies on viral infections, including COVID-19 and HIV
  • New studies on psychiatric disorders, neurodegenerative disorders, celiac disease and more
  • Coming soon: HumanDisease on Human Genome B38, OmicSoftGenCode.V33

HumanDisease

In this release, we added 7579 samples and 3234 comparisons from 137 projects to HumanDisease_B37. Among the many diseases covered in the new projects, a particular focus was on viral infection, including further studies on COVID-19, MERS and HIV, as well as studies on schizophrenia, autism spectrum, bipolar, celiac disease, diabetes and more.

Figure 4. Distribution of new Disease-focused samples in HumanDisease 2020R4, grouped on the Y-axis by DiseaseState and colored by Tissue. Normal control and Disease Control samples were hidden.

 

MouseDisease

With 4364 samples and 994 comparisons from 97 projects, MouseDisease_B38 has new content on allergy, Alzheimer's disease, autism spectrum, chronic kidney disease, graft-vs-host disease, Huntington's disease, toxoplasmosis and diabetes.

Figure 5. Distribution of new Disease model samples in MouseDisease 2020R4, grouped on the Y-axis by DiseaseState and colored by Tissue. Normal control and Disease Control samples were hidden.