The Regulator Effects analysis in IPA provides unprecedented insights into your data by integrating Upstream Regulator results with Downstream Effects results to create causal hypotheses that explain what may be occurring upstream to cause particular phenotypic or functional outcomes downstream.
- Explain biological impact of upstream molecules via genes they regulate
- Explain mechanism for a phenotype
- Define important drug targets
Regulator Effects creates the above hypothesis that the four upstream regulators MEF2A, PPARGC1B, HAND2 and the Creb protein family are activated, which in turn drives expression changes in the dataset (shown in the middle tier) to cause increased heart rate, contractility of heart, and contractility of muscle in general.
Learn more about regulator effects.