QIAGEN CLC Genomics Server is a multi-user, enterprise solution for high throughput sequencing analysis, designed for use on a central compute cluster or server. Along with a strong bioinformatics analysis offering, it can handle data volumes beyond the capacity of desktop systems and effectively manages the submission of many jobs via its own queuing system or through submission of jobs to a third party grid scheduler. It is designed to be easy and intuitive to use: a graphical interface for administration is included, and jobs can be submitted to the QIAGEN CLC Genomics Server through the user friendly, graphical menu system of the QIAGEN CLC Genomics Workbench or by using the command line.
QIAGEN CLC Genomics Server supports import and export of major bioinformatics file formats, such as fastq, fasta, BAM, VCF, BED and others, and provides bioinformatics tools for the analysis of next generation sequencing data in many application areas. Plugins further expand its functionality, including supplying ready-to-use workflows for application areas such as biomedical analysis, microbial genomic analysis, and QIAseq panel data analysis.
Workflows on QIAGEN CLC Workbenches can be executed on the QIAGEN CLC Genomics Server, or they can be exported and installed directly on the QIAGEN CLC Genomics Server, allowing the same workflow, with the same settings, to be employed by multiple users.
QIAGEN CLC Genomics Server can be run on computer clusters either as a QIAGEN job node setup or by integrating with an existing grid setup via a DRMAA interface. We have verified our grid integration on the following systems:
Data folders mounted from a central data storage system and attached to the compute cluster or server are accessible to via the server or client interfaces. Group-level access control can be applied via LDAP, Active Directory or the built-in access system, allowing administrators to fine tune who has access to different aspects of the server, such as read or write permissions on particular data folders, the ability to run certain tasks, access to particular grid queues, and so on.
The QIAGEN CLC Genomics Server’s External Applications functionality allows the integration of non-interactive, command line software, such as many open source bioinformatics tools, such that they can be launched via the graphical menu system of the QIAGEN CLC Genomics Workbench, independently or as part of a workflow, or launched using the CLC Server Command Line Tools.
In addition, a flexible plugin system utilized by the API and our Software Development Kit makes it possible to tightly integrate your own algorithms directly into the software, making them available to launch via the client software of the QIAGEN CLC Genomics Server.
Further customized functionality is available through the QIAGEN CLC Informatics Custom Solutions team, who provide a comprehensive suite of consulting, development, training, and other professional services.
The Genomics Analysis Portal allows sample- and workflow-centric views of analyses run on the QIAGEN CLC Genomics Server. It provides a graphical interface for launching workflows and viewing information about the analyses which have run, including progress and details about individual analyses. In addition, if BaseSpace is configured, data stored in the Illumina BaseSpace environment can be accessed for analysis.