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Tox Lists and Tox Functions

Tox Lists and Tox Functions IPA-Tox helps you link experimental data to clinical pathology endpoints, to understand pharmacological response and to support mechanism of action and mechanism of toxicity hypothesis generation.

Tox Lists are sets of molecules that are known to be involved in a particular type of toxicity. These lists are hand-curated by our content scientists, and cover topics such as renal, hepatic and cardiac injury, among many others. They represent critical biological processes and key toxicological responses such as adaptive, defensive or reparative responses to xenobiotic insult, including genes associated with response to mitochondrial toxicants.


Tox Functions catalog the genes and molecules associated with toxicity endpoints and phenotypes, and their causal associations, when known. They include associations to organ injuries and clinical chemistry and hematology assays, as well as pathway-related endpoints such as peroxisomal proliferation, phospholipidosis, mitochondrial function and hyperbilirubinemia.


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