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Catalogue of Somatic Mutations in Cancer (COSMIC)

Explore the impact of somatic mutations in human cancer with the world’s largest and most comprehensive resource, COSMIC.

What is the impact?

Ever imagine what the impact of misidentifying the correct mutation could be on cancer or missing critical information in your research? What would the impact of missing an already identified variant be on your research? These questions are best left unanswered by choosing to work with only the best and most comprehensive database for human cancer mutations.

With over 23 million genomic variants, COSMIC is the world’s largest expert-curated somatic mutation database. Trusted by over 50,000 users, it is integral to any clinical assessment of somatic variants. Integrating COSMIC into your NGS pipeline accelerates cancer sample analysis by rapidly prioritizing cancer driver mutations, distinguishing VUSes, and determining if an alteration is common or rare in the cancer type of interest.

Discover the impact of mutations in human cancers

Empower your research and diagnosis with the world’s largest database of human cancer mutations

with well over 50,000 users and in excess of 10,000 citations


genomic variants

COSMIC provides genome wide annotation with over 23 million genomic variants across 6,800 precise cancer types.


total human samples

COSMIC includes over 1.5 million manually curated human samples, including 39,000 genomes with unbiased, genome-level profiling of diseases with objective frequency data.


peer-reviewed papers

Every four months, COSMIC content and features are updated to ensure you remain informed on the latest findings.

View the complete COSMIC database statistics here.
See what’s new in the latest COSMIC release (v96) here.

Ensure your patients receive trusted and timely information

As NGS panels increase in depth-of-gene coverage and more treatment options become available, labs need access to current data and relevant evidence to support actionable decision-making. 

However, every year you don’t renew your COSMIC license, your lab is not accessing the latest, high-quality information needed to drive accurate and actionable point-of-care decisions. COSMIC is constantly updated with the latest information on cancer mutations. 

Up-to-date content for informed decisions

Over the last 5 releases, COSMIC has increased the number of genomic mutations by over 15%.
                                                         Click here to watch tutorials

Mutation Actionability
in precision oncology

The sixth release of Actionability, the newest product in the COSMIC suite, is now available. Actionability is a vital tool for anyone working in precision oncology, offering expert-curated information on the availability and development of drugs targeting somatic mutations in cancer, as well as case studies, clinical trials, and regulatory body data critical to improving precision oncology decision-making.

COSMIC Actionability V6 Statistics
Investigation of Somatic and Germline Variants by COSMIC, HGMD and QIAGEN Knowledge Base.

Identifying and studying actionable variants is of great interest to many investigators.

Watch this webinar recording, where COSMIC, HGMD and QIAGEN Knowledge Base is introduced for annotation and investigation of both somatic and germline variants.


Making a difference in the cancer landscape

COSMIC has been fueling cancer research for the past 15 years. From its humble beginnings, see how this knowledge base plays its part in the fight against cancer and making a difference in patient care.

Interested in knowing more?

Explore how COSMIC can fuel your research into the etiology of cancer and the discovery of new drug targets.

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