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Catalogue of Somatic Mutations in Cancer (COSMIC)

Explore the impact of somatic mutations in human cancer with the world’s largest and most comprehensive resource, COSMIC.

What is the impact?

Ever imagine what the impact of misidentifying the correct mutation could be on cancer or missing critical information in your research? What would the impact of missing an already identified variant be on your research? These questions are best left unanswered by choosing to work with only the best and most comprehensive database for human cancer mutations.

COSMIC is the largest, expert curated manual resource for finding cancer-causing mutations. Founded and maintained by the Wellcome Sanger Institute in 2004, the database attempts to collate all known (published) genetic mutations responsible for human cancers, giving you the best resource for better research and patient outcomes.

Discover the impact of mutations in Human Cancers

Empower your research and diagnosis with the world’s largest database of human cancer mutations

with well over 20,000 users and in excess of 10,000 citations


curated coded mutations

COSMIC provides genome wide annotation with over 37 million coding mutations plus substantial coverage of  all other oncogenic non-coding regions.


human samples studied

Expert curated data, standardized and evaluated for accuracy from peer-reviewed papers by a team of post-doctoral scientists.


peer-reviewed papers

Every four months, COSMIC content and features are updated to ensure you remain informed on the latest findings.

View the complete COSMIC database statistics here.

See what’s new in the latest COSMIC release (v92) here.

COSMIC is constantly being updated with the latest information on cancer mutations. With over 5,000,000 Legacy COSM mutations added in 2019 to 2020, almost double the coding mutations that have been collected over the past 15 years.

Created with Highcharts 8.2.2YearNumber of coding mutationsCoding mutations added to COSMIC every year20102012201420162018202002.5M5M7.5M10M12.5M15MNovember 2017 coding mutations: 5 366 273
                                                         Click here to watch more tutorials

QIAGEN is delighted to offer the COSMIC Database from the Sanger Wellcome Institute. COSMIC joins QIAGEN's comprehensive portfolio of somatic interpretation solutions.

Jonathan Sheldon, PhD

Senior Vice President, QIAGEN Digital Insights

Making a difference in the cancer landscape

COSMIC has been fueling cancer research for the past 15 years. From its humble beginnings, see how this knowledge base plays its part in the fight against cancer and making a difference in patient care.

MARCH 25 | 11 AM ET| 8 AM PT
COSMIC webinar: Describing millions of somatic mutations at high resolution across every form of cancer underpins precision oncology research

On March 25, please join us for a LIVE webinar where Dr. Simon Forbes, Head of COSMIC from Wellcome Sanger Institute, (Cambridge, UK) will introduce COSMIC and its hand-curated content, review its functionalities in detail as well as upcoming features.

Interested in knowing more?

Speak to a QIAGEN subject matter expert

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