Catalogue of Somatic Mutations in Cancer (COSMIC)

Explore the impact of somatic mutations in human cancer with the world’s largest and most comprehensive resource, COSMIC.

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What is the impact?

Ever imagine what the impact of misidentifying the correct mutation could be on cancer or missing critical information in your research? What would the impact of missing an already identified variant be on your research? These questions are best left unanswered by choosing to work with only the best and most comprehensive database for human cancer mutations.

With over 71 million somatic mutations, COSMIC is the world’s largest expert-curated somatic mutation database. Trusted by over >20.000 users, it is integral to any clinical assessment of somatic variants. Integrating COSMIC into your NGS pipeline accelerates cancer sample analysis by rapidly prioritizing cancer driver mutations, distinguishing VUSes, and determining if an alteration is common or rare in the cancer type of interest.

Discover the impact of mutations in Human Cancers

Empower your research and diagnosis with the world’s largest database of human cancer mutations

with well over 20,000 users and in excess of 10,000 citations

38,343,693

curated coded mutations

COSMIC provides genome wide annotation with over 38 million coding mutations plus substantial coverage of all other oncogenic non-coding regions.

1,491,000+

human samples studied

Expert curated data, standardized and evaluated for accuracy from peer-reviewed papers by a team of post-doctoral scientists.

28,000+

peer-reviewed papers

Every four months, COSMIC content and features are updated to ensure you remain informed on the latest findings.

View the complete COSMIC database statistics here.

See what’s new in the latest COSMIC release (v94) here.

COSMIC is constantly being updated with the latest information on cancer mutations. With over 5,000,000 Legacy COSM mutations added in 2019 to 2020, almost double the coding mutations that have been collected over the past 15 years.

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COSMIC Webinar: On-demand

Describing millions of somatic mutations at high resolution across every form of cancer underpins precision oncology research

Watch the on-demand webinar where Dr. Simon Forbes, Head of COSMIC and Dr. Zbyslaw Sondka, Senior Scientist of COSMIC, from the Wellcome Sanger Institute, (Cambridge, UK) will introduce COSMIC and its hand-curated content, review its functionalities in detail with East Asian cancer patients cohorts as well as talk about the upcoming features.

New product in the COSMIC suite

Mutation Actionability in Precision Oncology

On March 24, COSMIC released Actionability which is aimed to indicate the availability of drugs that target mutations in cancer and track the progress of clinical studies towards making new drugs available. Drugs that target somatic mutations are represented at all stages of drug development, through safety and clinical phases to market and repurposing, with additional case studies.

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Investigation of Somatic and Germline Variants by COSMIC, HGMD and QIAGEN Knowledge Base.

Identifying and studying actionable variants is of great interest to many investigators.

Watch this webinar recording, where COSMIC, HGMD and QIAGEN Knowledge Base is introduced for annotation and investigation of both somatic and germline variants.

QIAGEN is delighted to offer the COSMIC Database from the Sanger Wellcome Institute. COSMIC joins QIAGEN's comprehensive portfolio of somatic interpretation solutions.

Jonathan Sheldon, PhD

Senior Vice President, QIAGEN Digital Insights

Making a difference in the cancer landscape

COSMIC has been fueling cancer research for the past 15 years. From its humble beginnings, see how this knowledge base plays its part in the fight against cancer and making a difference in patient care.