Read about how researchers across the world are using QIAGEN Digital Insights solutions to accelerate their work in a variety of applications
Making sense of complex ‘omics data, and developing the infrastructure to compile, store, search, analyze and visualize relevant information has significant challenges and may pose a burden to researchers without bioinformatics skills. Yet powerful insights derived from ‘omics data help innovate, integrate and translate scientific results into impactful discoveries. Many noteworthy papers cite QIAGEN Digital Insights solutions and demonstrate how our tools help drive research insights and discoveries. These papers use QIAGEN Ingenuity Pathway Analysis (IPA), QIAGEN CLC Genomics and/or QIAGEN OmicSoft to help drive success. The QIAGEN Digital Insights portfolio encompasses a comprehensive, easy-to-use toolbox that ensures continuity in the NGS workflow. Here, we have curated a selection of just a few recent papers to offer a sense of the diversity of the research for which QIAGEN Digital Insights solutions makes a difference.
Multi-organ proteomic landscape of COVID-19 autopsies
First author: Xui Nie
Check out this fantastic work by coronavirus researchers at Westlake University who try to understand how SARS-CoV-2 causes cellular damage in organs other than the lungs. See how the team uses QIAGEN IPA to identify upregulated molecules and activated pathways in this proteomic study of COVID-19 autopsy samples. Read their full paper here.
EGR1 is a gatekeeper of inflammatory enhancers in human macrophages
First author: Marco Trizzino
Monocytes or macrophages? See how the team at The Wistar Institute used QIAGEN IPA to understand how EGR1 drives immune cell differentiation by studying upstream regulators of the genes associated with EGR1. Read the full article here.
Wastewater-based epidemiology as a useful tool to track SARS-CoV-2 and support public health policies at the municipal level in Brazil
First author: Tatiana Prado
We’ve heard wastewater can be used for COVID-19 surveillance. Check out this QIAGEN CLC research paper on wastewater-based epidemiology as a useful tool to track SARS-CoV-2 in Brazil. Read the full article here.
KLF10 deficiency in CD4+ T cells triggers obesity, insulin resistance and fatty liver
First author: Akm Khyrul Wara
Is immune dysregulation and obesity/insulin resistance connected? Researchers at Harvard Medical use QIAGEN IPA and QIAGEN CLC Genomics to study the role of CD4+ T cells in insulin resistance and obesity to reveal how KLF10, a transcription factor and a critical regulator of CD4+ T regulatory cells, maybe be responsible. Read the full article here.
Single-cell analysis reveals distinct immune landscapes in transplant and primary sarcomas that determine response or resistance to immunotherapy
First author: Amy J. Wisdom
Does immunotherapy work differently in primary vs. transplanted tumors? See how cancer researchers at Duke University use QIAGEN OmicSoft Suite for single-cell analysis of immune cells found in transplant vs. primary tumors and how these cells play a role in the effectiveness of immunotherapy. Read the full paper here.
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