QIAGEN Digital Insights Publication Roundup (Fall 2020)

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QIAGEN Digital Insights

QIAGEN Digital Insights Publication Roundup (Fall 2020)

Read about how researchers across the world are using QIAGEN Digital Insights solutions to accelerate their work in a variety of applications

Powerful insights help innovate, integrate and translate scientific results into impactful discoveries. Many noteworthy papers cite QIAGEN Digital Insights solutions and demonstrate how our tools help drive research insights and discoveries. These papers use QIAGEN Ingenuity Pathway Analysis (IPA),  QIAGEN CLC and/or QIAGEN OmicSoft to help drive success. The QIAGEN Digital Insights portfolio encompasses a comprehensive, easy-to-use toolbox that ensures continuity in NGS workflow. Here, we have curated a selection of just a few recent papers to offer a sense of the diversity of the research for which QIAGEN Digital Insights solutions makes a difference. 

QIAGEN IPA


Pro-efferocytic nanoparticles are specifically taken up by lesional macrophages and prevent atherosclerosis

First author: Alyssa M. Flores

Discover this fascinating nanotechnology research out of Stanford University by Dr. A Flores and colleagues, who investigate phagocytosis as a therapy for clearing atherosclerotic plaques. See how the team uses QIAGEN IPA to show the effectiveness of drug dispensing nanoparticles in reducing pro-inflammatory pathways and potentially preventing atherosclerosis. Read their full paper here.

 


Elevated calprotectin and abnormal myeloid cell subsets discriminate severe from mild COVID-19

First author: Aymeric Silvin

Don’t miss this critical research by Dr. A. Silvin and colleagues from Inserm, who investigate biomarkers to predict the development of severe COVID-19 in patients. Delve into their study, and learn how QIAGEN IPA supports their understanding of how the accumulation of calprotectin and abnormal monocytes may help differentiate between severe and mild COVID-19. Read the full article here.

 


Type I and III interferons disrupt lung epithelial repair during recovery from viral infection

First author: Jack Major

Immunologists at the Francis Crick Institute investigate the harmful effects of excessive cytokine signaling during respiratory viral infection. Learn how they use QIAGEN IPA to investigate how IFN signaling interferes with lung repair during influenza/viral recovery. Read their full paper in Science here.

 


Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and – independent cellular responses in Alzheimer’s disease

First author: Yingyue Zhou

Are we a step closer to understanding Alzheimer’s risk? Learn about fascinating research by Y. Zhou and colleagues at Washington University in St. Louis who study the role of microglia receptor TREM2 in Alzheimer’s pathogenesis. See how they use QIAGEN IPA to investigate how TREM2 increases AD risk and activation of disease-associated microglia.  Read the full article here.

 


Elevated glucose levels favor SARS-CoV-2 infection and monocyte response through a HIF-1α/glycolysis-dependent axis

First Author: Ana Campos Codo

Discover why diabetic patients may be more at risk of developing severe COVID-19. Researchers at the Universidade Estadual de Campinas investigate the role of elevated blood glucose levels in inducing cytokine storms in severe COVID-19 patients. See how the team uses QIAGEN IPA to investigate how the HIF-1α axis in monocytes causes T-cell dysfunction and reduces epithelial cell survival.  Read their full paper here.

 

QIAGEN CLC Genomics


Genetic tracing of HCoV-19 for the re-emerging outbreak of COVID-19 in Beijing, China

First author: Jing Yang

Crucial coronavirus research from the Chinese Academy of Sciences looking into the re-emergence of the SARS-CoV-2 virus in China. Discover how they use the nanopore and MiSeq system together with QIAGEN CLC Genomics Workbench to trace the source of the virus in this second outbreak in Beijing. Get the full article here.

 


Systematic reconstruction of the complete two-component sensorial network in Staphylococcus aureus

First author: B. Rapun-Araiz

High-impact research by B. Rapun-Araiz and colleagues at Universidad Publica de Navarra in Spain who investigate the targets of two-component signal transduction systems (TCSs) in bacteria. See how they use QIAGEN CLC Genomics Workbench to map the complete TCS regulon in Staphylococcus aureus.  Read the full paper here.

 


Remdesivir inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice

First author: Andrea J. Pruijssers

Excellent research by A. Pruijssers and colleagues at Vanderbilt University who study how Remdesivir inhibits SARS-CoV-2 in human lung cells. See how they use QIAGEN CLC Main Workbench to help investigate the efficacy of Remdesivir against SARS-CoV-2 in vitro and in vivo.  Read the full article here.

 


Lysosomal recycling of amino acids affects ER quality control

First author: Ryo Higuchi-Sanabria

Exciting research from the Howard Hughes Medical Institute, where researchers investigate the role of lysosomes in amino acid recycling. Learn how they use QIAGEN CLC Genomics Workbench to understand how reduced lysine and arginine can cause increased sensitivity to proteotoxic stress in the endoplasmic reticulum (ER).  Read the full paper here.

 

QIAGEN OmicSoft


Elucidation of mechanisms of topotecan-induced cell death in human breast MCF-7 cancer cells by gene expression analysis

First author: Birandra K. Sinha

Fascinating research by Dr. B Sinha and colleagues at the National Institute of Environmental Health Sciences (NIEHA), who investigate the mechanisms of topotecan-induced cell death in human breast cancer cells. Learn how the team uses QIAGEN OmicSoft Studio to understand the role of reactive oxygen species in inducing tumor cell killing. Read the full paper here.

 


ABHD11, a new diacylglycerol lipase involved in weight gain regulation

First author: Johanna Escoubet

Exciting discovery by J. Escoubet and colleagues at Sanofi who study a new diacylglycerol lipase involved in weight gain regulation. Learn how they use QIAGEN ArrayStudio to understand how inhibiting ABHD11 helps reduce intestinal fat absorption.  Read the full paper here.

 

To request information on the QIAGEN Digital Insight solutions, contact bioinformaticssales@qiagen.com.