QCI Interpret Translational
Rapid, evidence-powered NGS variant annotation, filtering and triage
NGS VARIANT ASSESSMENT SOFTWARE
From millions to meaningful
Whole-exome sequencing (WES) using next-generation sequencing (NGS) technology is a powerful tool for investigating variants linked to genetic disease. It provides a high-resolution, unbiased view across the entire exome to discover causative variants of inherited disorders. However, the vast amounts of data produced by WES require comprehensive data analysis tools that can efficiently translate the raw sequencing data into meaningful, interpretable results. To address these challenges, QIAGEN Digital Insights offers QCI Interpret Translational.
QCI Interpret Translational
QCI Interpret Translational is a NGS variant assessment software solution that enables rapid, evidence-powered variant annotation, filtering, and triage for human exome, genome, and large cohort sequencing data.
Leveraging the QIAGEN Knowledge Base, the industry’s largest collection of biological and clinical findings, QCI Interpret Translational improves research efficiency and accuracy by automating manual curation processes, dynamically and transparently assessing variants according to society guidelines with full user-control, and optimizing resource allocation, allowing users to focus on what matters most: transforming genomic data into publishable insights.
Eliminate manual curation
Connected to the QIAGEN Knowledge Base, QCI Interpret Translational brings all the information needed for variant assessment together in one location.
Accelerate variant filtering
Leveraging powerful algorithms and trusted content, QCI Interpret Translational applies proprietary filters to rapidly identify potential causal variants within minutes.
Retain full user-control
Unlike other software, QCI Interpret Translational computes assessments with full transparency, giving users control over parameters, policies, and output.
Eliminate manual curation
QCI Interpret Translational rapidly identifies the most compelling disease variants in human sequencing data by combining powerful analytical tools and unparalleled content from the QIAGEN Knowledge Base.
The QIAGEN Knowledge Base is the industry’s largest collection of biological and clinical findings, with roughly 2,000,000 unique variants expertly curated from over 300,000 scientific articles, including 140,000 variants connected to the top 200 newborn/carrier screening genes.
Learn more about the QIAGEN Knowledge Base here.
Accelerate variant filtering
QCI Interpret Translational compiles all gene variants within a dataset and enables this list to be quickly narrowed down through an interactive series of filters. This Interactive Filter Cascade can be adopted to reflect selection criteria of interest and their importance to the research question at hand.
Proprietary Interactive Filter Cascade
Integrated features for rapid variant annotation, filtering and triage
QCI Interpret Translational offers a comprehensive workflow for efficient, evidence-powered variant assessment.
Sample Management
Upload and organize sample data files based on specific projects or by pipeline, and annotate files with detailed descriptions for easy tracking.
Virtual Gene Panels
Create and rapidly compare evidence-based virtual gene panels.
Variant Filter Builder
Access 4 different filters to triage variants with granular control:
- Confidence Filter (industry-wide)
- Common Variants Filter (industry-wide)
- Predictive Deleterious Filter (pre-computed ACMG classifications; pathogenic vs. non-pathogenic)
- Biological Context Filter (exclusive to QIAGEN)
Familial Variant Analysis
Perform family-based variant filtering by comparing different modes of inheritance to identify inherited and de novo variants.
Dynamic Variant Assessment
Pre-classify variants using weighted evidence according to the ACMG five-tier classification system to determine variant pathogenicity and actionability.
Variant Export
Export annotated variants that passed each stage of the filtering cascade to review annotations, document test results, or analyze the data outside of QCI Interpret Translational.
Retain full user-control
QCI Interpret Translational performs all computations with total transparency and traceability and gives users full-control over filter criteria, parameters, and variant assessments.
Transparent Traceability
Easily view how and why a variant was classified with the ability to change final assessments depending on your experience and judgment.
Bibliographic Reference Citations
Receive clickable hyperlinks to the direct source material considered and/or used during variant assessment.
Try QCI Interpret Translational for free
Did you know we offer complimentary trials of our software? No restricted features, no sample data – you get to try all the features of QCI Interpret Translational with your data and see how it works.
Interested in QIAGEN's human exome NGS panels?
Learn more about QIAGEN’s QIAseq Human Exome Kits.
Resources
On-Demand Webinar
Preview QCI Interpret Translational in an on-demand webinar from our experts.
Expert Article
Discover how your lab can break the bottleneck in clinical genetic testing.
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